Instructors: 한순규 (Sunkyu Han, sunkyu.han@kaist.ac.kr)

Class: MW 13:00-14:30

Class Lecture Hall: Building E6-4, room# 3130

Website: synthesis.kaist.ac.kr/orgmol

Office Hours: Mon 14:30~16:00, Fri 13:30~15:00

Teaching Assistant: 강규민 (Gyumin Kang, kkggml@kaist.ac.kr)

Course Description:

-        Modern spectroscopic techniques used for structure elucidation of organic compounds and spectra data analysis techniques will be discussed.

-        Lectures on natural products biosynthesis and structure determination will be given at the end of the course.

-        This course is specifically designed for those who will be actually practicing the structure determination of organic molecules for his/her research project.

Supplementary Textbook:

-        Major contents of the course will be introduced via PPT lecture slides.

-        “Organic Structural Spectroscopy” International 2^nd Edition, J. B. Lambert, S. Grone, H. F. Shurvell, D. A. Lightner, Pearson.

-        “Organic Structure Determination Using 2-D NMR Spectroscopy: A Problem-Based Approach” by Jeffrey H. Simpson (Textbook with many NMR problems.

-        “Organic Chemistry” 2^nd Edition, J. Clayden, N. Greeves, S. Warren, Oxford

-        "Medicinal Natural Products: A Biosynthetic Approach" 3rd edition by Paul M. Dewick, Wiley 

Lecture Slides

Practice Problems & Past Exams

Grading Policy

Course Participation: 10

Midterm Exam: 45

Final Exam: 45

Exams Information

Midterm Exam

Date: Nov. 09 (Sat)

Time: 1 - 5pm

Venue: Building E6-4, room# 3130.

Claim session: TBA

Final Exam

Date: Dec. 16 (Mon)

Time: 12:30 - 4pm

Venue: Building E6-4, room# 3130.

Claim session: TBA

Course Schedule

Week	Date	Themes	Contents
1	09/02,04	Introduction	Introduction to Organic Structure Determination Introduction to NMR
2	09/09	1D NMR	Basic Principles of NMR No Class on 09/11 (Chuseok Preparation)
3	09/16,18	1D NMR	NMR Chemical Shift, Determination of Stereochemistry in Proton NMR, Coupling Constants
4	09/23,25	1D NMR	Coupling Constants, Murata J-Based Method
5	10/02	1D NMR	Long Range, Second Order Coupling, NOE No Class on 09/30 (ACP Meeting)
6	10/07	1D NMR	2D NMR (COSY, HSQC, HMBC) No Class on 10/09 (한글날)
7	10/14	2D NMR	2D NMR (TOCSY, NOESY, DEPT, INADEQUATE) No Class on 10/16 (KCS Meeting, 대한화학회)
8		Midterm Period	No Class on 10/21,23 (Midterm Period)
9	10/28,30	2D NMR	2D NMR Problem Solving
10	11/04,06,09	2D NMR Mass Spec	2D NMR Problem Solving Mass Spec Instrumentation: Ionization Nov. 09 (Sat) 1 pm: Midterm
11	11/11,13	Mass Spec	Mass spec Instrumentation: Mass Analyzer
12	11/18,20	Mass Spec	Mass Spec Fragment Analysis
13	11/25,27	IR, X-ray, Natural Products Biosynthesis	IR and Practical X-ray analysis in organic chemistry Natural Products Biosynthesis (NRPS)
14	12/04	Natural Products Biosynthesis	Natural Products Biosynthesis (PKS) No Class on 12/02 (Korea-China Organic Chemistry Symposium)
15	12/09,11	Natural Products Biosynthesis	Natural Products Biosynthesis (Miscellaneous)
16	12/21	Final Exam	Dec. 16 (Mon) 12:30   pm: Final