CH437 Structure Determination and Comprehension of Organic Molecules

Instructors: 한순규 (Sunkyu Han, sunkyu.han@kaist.ac.kr)

Class: MW 13:00-14:30

Class Lecture Hall: Building E6-4, room# 3130

Website: synthesis.kaist.ac.kr/orgmol

Office Hours: Mon 14:30~16:00, Fri 13:30~15:00

Teaching Assistant: 강규민 (Gyumin Kang, kkggml@kaist.ac.kr)

Course Description:

-        Modern spectroscopic techniques used for structure elucidation of organic compounds and spectra data analysis techniques will be discussed.

-        Lectures on natural products biosynthesis and structure determination will be given at the end of the course.

-        This course is specifically designed for those who will be actually practicing the structure determination of organic molecules for his/her research project.

Supplementary Textbook:

-        Major contents of the course will be introduced via PPT lecture slides.

-        “Organic Structural Spectroscopy” International 2nd Edition, J. B. Lambert, S. Grone, H. F. Shurvell, D. A. Lightner, Pearson.

-        “Organic Structure Determination Using 2-D NMR Spectroscopy: A Problem-Based Approach” by Jeffrey H. Simpson (Textbook with many NMR problems.

-        “Organic Chemistry” 2nd Edition, J. Clayden, N. Greeves, S. Warren, Oxford

-        "Medicinal Natural Products: A Biosynthetic Approach" 3rd edition by Paul M. Dewick, Wiley 

Lecture Slides

Practice Problems & Past Exams

Grading Policy

Course Participation: 10

Midterm Exam: 45

Final Exam: 45

Exams Information

Midterm Exam

Date: Nov. 09 (Sat)

Time: 1 - 5pm

Venue: Building E6-4, room# 3130.

Claim session: TBA

Final Exam

Date: Dec. 16 (Mon)

Time: 12:30 - 4pm

Venue: Building E6-4, room# 3130.

Claim session: TBA


Course Schedule

Week

Date

Themes

Contents

1

09/02,04

Introduction

Introduction to Organic Structure Determination

Introduction to NMR

2

09/09

1D NMR

Basic Principles of NMR

No Class on 09/11 (Chuseok Preparation)

3

09/16,18

1D NMR

NMR Chemical Shift, Determination of Stereochemistry in Proton NMR, Coupling Constants

4

09/23,25

1D NMR

Coupling Constants, Murata J-Based Method

5

10/02

1D NMR

Long Range, Second Order Coupling, NOE

No Class on 09/30 (ACP Meeting)

6

10/07

1D NMR

2D NMR (COSY, HSQC, HMBC)

No Class on 10/09 (한글날)

7

10/14

2D NMR

2D NMR (TOCSY, NOESY, DEPT, INADEQUATE)

No Class on 10/16 (KCS Meeting, 대한화학회)

8

 

Midterm Period

No Class on 10/21,23 (Midterm Period)

9

10/28,30

2D NMR

2D NMR Problem Solving

10

11/04,06,09

2D NMR

Mass Spec

2D NMR Problem Solving

Mass Spec Instrumentation: Ionization

Nov. 09 (Sat) 1 pm: Midterm

11

11/11,13

Mass Spec

Mass spec Instrumentation: Mass Analyzer

 

12

11/18,20

Mass Spec

Mass Spec Fragment Analysis

13

11/25,27

IR, X-ray, Natural Products Biosynthesis

IR and Practical X-ray analysis in organic chemistry

Natural Products Biosynthesis (NRPS)

14

12/04

Natural Products Biosynthesis

Natural Products Biosynthesis (PKS)

No Class on 12/02 (Korea-China Organic Chemistry Symposium)

15

12/09,11

Natural Products Biosynthesis

Natural Products Biosynthesis (Miscellaneous)

16

12/21

Final Exam

Dec. 16 (Mon) 12:30   pm: Final