Instructor: 한순규 (Sunkyu Han, sunkyu.han@kaist.ac.kr)

Class: MW 13:00-14:30

Class Lecture Zoom ID: 421 775 5535

Class Lecture Zoom URL: https://kaist.zoom.us/j/4217755535

Website: synthesis.kaist.ac.kr/orgmol

Office Hours: Mon 14:30~16:00, Fri 13:30~15:00

Teaching Assistant: 정가람 (Garam Chung, garamchung@kaist.ac.kr)

Course Description:

-        Modern spectroscopic techniques used for structure elucidation of organic compounds and spectra data analysis techniques will be discussed.

-        Lectures on natural products biosynthesis and structure determination will be given at the end of the course.

-        This course is specifically designed for those who will be actually practicing the structure determination of organic molecules for his/her research project.

Textbook:

            -       Major contents of the course will be introduced via PPT lecture slides.

Supplementary Textbook:

-        Major contents of the course will be introduced via PPT lecture slides.

-        “Organic Structural Spectroscopy” International 2^nd Edition, J. B. Lambert, S. Grone, H. F. Shurvell, D. A. Lightner, Pearson.

-        “Organic Structure Determination Using 2-D NMR Spectroscopy: A Problem-Based Approach” by Jeffrey H. Simpson (Textbook with many NMR problems.

-        “Organic Chemistry” 2^nd Edition, J. Clayden, N. Greeves, S. Warren, Oxford

-        "Medicinal Natural Products: A Biosynthetic Approach" 3rd edition by Paul M. Dewick, Wiley 

Lecture Slides

Practice Problems & Past Exams

Grading Policy

Course Participation: 10

Midterm Exam: 45

Final Exam: 45

Exams Information

Midterm Exam

Date: Oct. 19, 2020

Time: 13:00 ~ 16:00

Venue: Building E6-4, room# 3130 + Zoom exam

Claim session: Oct. 26 in class

Final Exam

Date: Dec. 14, 2020

Time: 13:00 ~ 16:00

Venue: Building E6-4, room# 3130 + Zoom exam

Claim session: TBA

Course Schedule

Week	Date	Themes	Contents
1	08/31, 09/02	Introduction	Introduction to the course I Introduction to the course II
2	09/07,09	NMR	Basic Principles of NMR I Basic Principles of NMR II
3	09/14,16	1D NMR	NMR Chemical Shift, Determination of Stereochemistry in Proton NMR (Mosher Ester Analysis + CASA reagent), Introduction to Coupling Constants
4	09/21,23	1D NMR	Coupling Constants, Murata J-Based Method
5	09/28	1D NMR	Long Range, Second Order Coupling, NOE No Class on 09/30 (추석)
6	10/05,07	2D NMR	2D NMR (COSY, HSQC, HMBC) 2D NMR (TOCSY, NOESY, DEPT, INADEQUATE)
7	10/12,14	2D NMR	2D NMR Problem Solving 2D NMR Unknown Structure Determination
8	10/19	Midterm Exam	Midterm exam on 10/19 (Mon) 13:00 ~ 16:00 pm
9	10/26,28	Mass Spec	Midterm Review + Claim Session Mass Spec Instrumentation: Ionization
10	11/02,04	Mass Spec	Mass Spec Instrumentation: Application + Analyzer Mass Spec Fragment Analysis I
11	11/09,11	Mass Spec IR, X-ray, MicroED	Mass Spec Fragment Analysis II IR, Practical X-ray analysis, MicroED in organic chemistry
12	11/16,18	Natural Products Biosynthesis	Natural Products Biosynthesis (NRPS) I Natural Products Biosynthesis (NRPS) II
13	11/23,25	Natural Products Biosynthesis	Natural Products Biosynthesis (PKS) Natural Products Biosynthesis (Terpenes + Alkaloids)
14	11/30, 12/02	Review	Review Sessions
15	12/07,09	Review	Review Sessions
16	12/14	Final Exam	Final exam on 12/14 (Mon) 13:00 ~ 16:00 pm