Instructors: 한순규 (Sunkyu Han, sunkyu.han@kaist.ac.kr) Class: TTh 10:30-12:00 Class Lecture Hall: Building E6-4, room# 2124 (Lectures on the first two weeks will be delivered online at 10:30 am by the Zoom system. https://zoom.us/j/4217755535 , Meeting ID: 421-775-5535) Website: synthesis.kaist.ac.kr/orgreactsyn Office Hours: Mon 14:30~16:00, Wed 14:30~16:00 Teaching Assistant: 임형근 (Hyeonggeun Lim, rahzell@kaist.ac.kr) Course Prerequisites: Organic Chemistry I (CH221), Organic Chemistry II (CH223), Bioorganic Chemistry (CH325), Physical Organic Chemistry (CH336, encouraged) Course Description: - Important topics in organic chemistry will be discussed in depth with a spectrum ranging from classical examples to the state of the art cases. - This course discusses representative name reactions, their mechanism, and synthetic applications in organic chemistry. - This course is designed to be complementary to other organic chemistry courses such as Organometallic Chemistry (CH542), Organic Synthesis I (CH522), and Organic Synthesis II (CH523). In other words, pericyclic reactions and carbonyl chemistry (1,2 and 1,4 addition, stereochemistry) won’t be discussed in details in this course. - Details in drawing arrow-pushing mechanisms, heterocycles syntheses, detailed olefin synthesis methods, various olefin functionalizations, practical metal catalyzed cross-coupling reactions, metal catalyzed allylations, organolithium chemistry, Aggarwal chemistry, olefin metathesis, radical chemistry, strategies in complex molecules synthesis will be discussed. Textbook: - Strategic Applications of Named Reactions in Organic Synthesis, 1st Edition, by Laszlo Kurti and Barbara Czako Supplementary Resources: - Andrew G. Myers Chemistry 115Handouts (Harvard University) - Phil Baran Group Seminar Lecture (The Scripps ResearchInstitute) - David MacMillan Group Seminar Presentation(Princeton University) - Noah Burns Group Meetings (StanfordUniversity) - Ryan Shenvi Group Seminars (The Scripps ResearchInstitute) - Fukuyama Group Meeting Problems (The University of Tokyo) - Alison Frontier Not Voodoo (University of Rochester) - Jon Njardarson Top-SellingPharmaceuticals (University of Arizona) - Jon Njardarson Chemistry by Design (University of Arizona) - Brian Stoltz Group Literature Seminars (Caltech) - Allthings Metathesis (Umicore) - Elizabeth Jarvo Chem 125 Advanced Organic Chemistry (UC Irvine) - M. Christina White Organometallics Lecture Note (UIUC) - Eric Ferreira Group Seminars (University of Georgia)
- James Morken Group Presentations (Boston College) Grading Policy Course Participation: 10 Midterm Exam: 40 Final Exam: 50 (cumulative with an emphasis on the second half of the course) Midterm exam
Final Exam
Course Schedule
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