CH437: Organic Structure Determination

 

Instructors: 한순규 (Sunkyu Han, sunkyu.han@kaist.ac.kr)

Class: MW 13:00-14:30

Class Lecture Hall: Building E6-4, room# 3130

Website: https://synthesis.kaist.ac.kr/orgspec

Office Hours: Fr 15:00~16:30,  Sat 13:30~15:00

Teaching Assistant:     김건 (Geon Kim, geon0202@kaist.ac.kr)

Course Description:

-       Modern spectroscopic techniques used for structure elucidation of organic compounds and spectra data analysis techniques will be discussed.

-       This course is specifically designed for those who will be actually practicing the structure determination of organic molecules for his/her research project.

-    Special lectures on natural products biosynthesis will be given at the end of the course.

Textbook:

-       “Organic Structural Spectroscopy” International 2nd Edition, J. B. Lambert, S. Grone, H. F. Shurvell, D. A. Lightner, Pearson.

Supplementary Textbooks:

-       “Organic Structure Determination Using 2-D NMR Spectroscopy: A Problem-Based Approach” by Jeffrey H. Simpson (Texbook with many NMR problems. This book is available free of charge via internet: http://www.sciencedirect.com/science/book/9780123849700).

-       Organic Chemistry” 2nd Edition,J. ClaydenN. Greeves, S. WarrenOxford-    “Organic Structure Analysis” International 2nd Edition. P. Crews, J. Rodriguez, M. Jaspars, Oxford University Press.

-      "Medicinal Natural Products: A Biosynthetic Approach" 3rd adition by Paul M. Dewick, Wiley -       “Spectrometric Identification of Organic Compounds” 7th Edition, R. M. Silverstein, F. X. Webster, D. J. Kiemle, Wiley.

-       “Introduction to Spectroscopy” 4th Edition, D. L. Pavia, G. M. Lampman, G. S. Kriz, Harcourt College Publishers.

Lecture Slides

Course Materials

Exams and Practice Problems

Grading Policy

Course Participation: 10

Midterm Exam: 45

Final Exam: 45

Exams

    Midterm Exam

  • Date: 2017, Nov 04 (Sat).
  • Time: 2:00 pm - 5:00 pm.
  • Venue: E6-4 room# 3130
  • Claim Session: TBD
  • Questions and Solution

    Final Exam

  • Date: 2017, Dec 11 (Mon).
  • Time: 1 pm - 4 pm.
  • Venue: E6-4 room# 3130
  • Claim Session: TBD
  • Questions and Solutions.

Course Schedule (Course schedule is subject to change)

Week

Date

Themes

Contents

1

08/30

Introduction

Introduction to the course

08/28: No class due to Award Interview

2

09/04,06

1D NMR

Introduction to NMR, Principles of NMR, Chemical Shift

3

09/11,13

1D NMR

Chemical Shift, Determination of Stereochemistry in Proton NMR, Coupling Constants

4

09/18,20

1D NMR

Coupling Constants, Determination of Stereochemistry by 1D-1H NMR

5

09/25,27

1D and 2D NMR

NOE, Multidimensional NMR Techniques

6

-

Chuseok

10/02,04: Chuseok Holidays

7

-

한글날

10/09: 한글날 National Holiday

10/11: No class due to prospective undergraduate students evaluations

8

-

-

10/16,18: No class due to midterm period

9

10/23,25

2D NMR

Multidimensional NMR Techniques

10

10/30, 11/01

NMR and Mass Spec

Practice NMR Problem.

and Mass Spec Instrumentation: Ionization

11/04 (Sat): Midterm Exam

11

11/06,08

Mass Spec

Mass spec Instrumentation: Mass Analyzer

and Mass Spec Fragment Analysis

12

11/13,15

NMR and Mass Spec

Mass Spec Fragment Analysis

13

11/20,22

IR, X-ray, Natural Products Biosynthesis

IR and Practical X-ray analysis in organic chemistry,

Natural Products Biosynthesis (NRPS)

14

11/27

Natural Products Biosynthesis

Natural Products Biosynthesis (PKS)

11/29: No class due to prospective undergraduate students interview

15

12/04,06

Natural Products Biosynthesis

Natural Products Biosynthesis (Miscellaneous)

16

Final Exam

Final Exam

12/11 Final Exam (Cumulative), 1-3:45 pm