CH437: Organic Structure Determination

 

Instructors: 한순규 (Sunkyu Han, sunkyu.han@kaist.ac.kr)

Class: MW 13:00-14:30

Class Lecture Hall: Building E6-4, room# 3130

Website: https://synthesis.kaist.ac.kr/orgspec

Office HoursMon 14:30~16:00, Fri 13:30~15:00

Teaching Assistant:     김태형, Taehyung Thomas Kim (thomasth.kim@kaist.ac.kr)

Course Description:

-       Modern spectroscopic techniques used for structure elucidation of organic compounds and spectra data analysis techniques will be discussed.

-       This course is specifically designed for those who will be actually practicing the structure determination of organic molecules for his/her research project.

-    Special lectures on natural products biosynthesis will be given at the end of the course.

Textbook:

-       “Organic Structural Spectroscopy” International 2nd Edition, J. B. Lambert, S. Grone, H. F. Shurvell, D. A. Lightner, Pearson.

Supplementary Textbooks:

-       “Organic Structure Determination Using 2-D NMR Spectroscopy: A Problem-Based Approach” by Jeffrey H. Simpson (Texbook with many NMR problems. This book is available free of charge via internet: http://www.sciencedirect.com/science/book/9780123849700).

-       Organic Chemistry” 2nd Edition,J. ClaydenN. Greeves, S. WarrenOxford-    “Organic Structure Analysis” International 2nd Edition. P. Crews, J. Rodriguez, M. Jaspars, Oxford University Press.

-      "Medicinal Natural Products: A Biosynthetic Approach" 3rd adition by Paul M. Dewick, Wiley -       “Spectrometric Identification of Organic Compounds” 7th Edition, R. M. Silverstein, F. X. Webster, D. J. Kiemle, Wiley.

Lecture Slides

Course Materials

Exams and Practice Problems

Grading Policy

Course Participation: 10

Midterm Exam: 45

Final Exam: 45

Exams

    Midterm Exam

  • Date: 2018, Nov 03 (Sat).
  • Time: 1:00 pm - 4:00 pm.
  • Venue: E6-4 room# 3130
  • Claim Session: TBD
  • Questions and Solution

    Final Exam

  • Date: 2018, Dec 10 (Mon).
  • Time: 1 pm - 3:45 pm.
  • Venue: E6-4 room# 3130
  • Claim Session: TBD
  • Questions and Solutions.

Course Schedule (Course schedule is subject to change)

Week

Date

Themes

Contents

1

08.27,29

Introduction

Introduction to Organic Structure Determination

Introduction to NMR

2

09.03

1D NMR

Basic Principles of NMR

No Class on 09.05 (Samsung AI Symposium)

3

09.10,12

1D NMR

NMR Chemical Shift, Determination of Stereochemistry in Proton NMR, Coupling Constants

4

09.17,19

1D NMR

Coupling Constants, Murata J-Based Method

5

-

Chuseok

No Class on 09.24,26 (Chuseok)

6

10.01

1D NMR

Long Range, Second Order Coupling, NOE

No Class on 10.03 (National Foundation Day)

7

10.08

2D NMR

2D NMR (COSY, HSQC, HMBC)

No Class on 10.10 (Prospective Undergraduate Students’ Applications Evaluation)

8

 

Midterm Period

No Class on 10.15,17 (Midterm Period)

9

10.22,24

2D NMR

2D NMR (TOCSY, NOESY, DEPT, INADEQUATE)

2D NMR Problem Solving

10

10.29,31

2D NMR

Mass Spec

2D NMR Problem Solving

Mass Spec Instrumentation: Ionization

11/03 (Sat): Midterm Exam

11

11.05

Mass Spec

Mass spec Instrumentation: Mass Analyzer

No Class on 11.07 (Tateshina Conference)

12

11.12,14

Mass Spec

Mass Spec Fragment Analysis

13

11.19,21

IR, X-ray, Natural Products Biosynthesis

IR and Practical X-ray analysis in organic chemistry

Natural Products Biosynthesis (NRPS)

14

11.26

Natural Products Biosynthesis

Natural Products Biosynthesis (PKS)

No Class on 11.28 (Prospective Undergraduate Students Interview)

15

12.03,05

Natural Products Biosynthesis

Natural Products Biosynthesis (Miscellaneous)

16

12.10

Final Exam

12/10 (Mon) Final Exam (Cumulative), 1-3:45 pm